Paracellin
WebHypokalemia can result from insufficient dietary potassium intake, intracellular shifting of potassium from the extracellular space, or potassium loss (renal or extra-renal) ( Table 21–3 ). Genetic disorders can be associated with some electrolyte disturbances ( eTable 21–1 ). A low dietary potassium intake is usually not sufficient as the ... WebA new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the hypomagnesemia …
Paracellin
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WebBackground: A new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the … WebOct 1, 2008 · They found that FHHNC was caused by mutations in paracellin-1, which is now considered to be claudin-16. In the past few years, research in this area has proliferated, and several comprehensive general reviews of this have recently been published (89, 99, 103). In this article, we focus on reviewing recent discoveries …
WebAug 1, 2007 · a Detection of paracellin-1 transcripts in human salivary glands by RT-PCR. A Gl. submandibularis, C Gl. parotis, E Gl. labialis, G Gl. sublingualis; B, D, F, H controls lacking reverse transcriptase. WebJul 1, 2001 · A new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption ...
WebMutations in PCLN-1, which encodes the renal tight junction protein paracellin-1 (claudin-16), were identified as the underlying genetic defects. Comprehensive clinical data and the results of PCLN-1 mutation analysis of 25 FHHNC families with 33 affected individuals … WebIn immunohistochemical studies paracellin-1 colocalised in the salivary excretory ducts with the tight junction proteins ZO-1 and occludin suggesting a potential role in paracellular calcium and magnesium transport. In the acini no such colocalisation was observed; …
WebParacellin-1 is a tight junction protein, which regulates the paracellular Mg 2+ transport in the TAL. We hypothesize that CsA reduces the expression and function of paracellin-1 and accounts for the observed renal Mg 2+ wasting. Methods. We established an immortalized cultured cortical TAL (cTAL) cell line from L-PK/Tag1 transgenic mice by ...
WebFeb 13, 2007 · Paracellin-1 (claudin-16), encoded by the PCLN-1 gene, was a key player in paracellular Mg 2+ reabsorption in the thick ascending limb (TAL) and was found to play an important role in the Mg 2+ renal handling [ 3]. Prolonged ciclosporin (CsA) usage is associated with the development of lower serum Mg 2+ levels. the voice break every chain 2022WebJul 2, 1999 · In a lovely dance between clinical and basic science, the report by Simon et al. now reveals that paracellin-1 regulates the resorption of Mg 2+ through paracellular channels in the kidney tubule. Unlike other ions such as Na +, K +, and Ca 2+, which … the voice breakersWebFamilial hypomagnesemia with hypercalciuria and nephrocalcinosis is an autosomal recessive renal tubular disorder characterized by renal magnesium wasting, hypercalciuria, advanced nephrocalcinosis and progressive renal failure. Mutations in the paracellin-1 (CLDN16) gene have been defined as the underlying genetic defect. the voice brelWebBACKGROUND: A new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the … the voice braydenWebFHHNC results from mutations in paracellin-1, a tight-junction protein that appears to be important in conducting or regulating paracellular cation transport. Impaired function of paracellin-1 leads specifically to urinary losses of magnesium and calcium, but because … the voice breathworkWebA new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the hypomagnesemia hypercalciuria syndrome (HHS). However, no functional experiments have demonstrated that TAL ... the voice britton buchanan battleWebJul 2, 1999 · In a lovely dance between clinical and basic science, the report by Simon et al. now reveals that paracellin-1 regulates the resorption of Mg 2+ through paracellular channels in the kidney tubule. Unlike other ions such as Na +, K +, and Ca 2+, which depend on active resorption, Mg 2+ is resorbed largely by transport through the … the voice brenl