WebJul 13, 2007 · Transcription factors of the interferon regulatory factor (IRF) family commands the entire type I interferon (IFN) system from induction of IFNs to diverse IFN responses, thereby providing a principal basis for host resistance against pathogens. However, the family has various additional roles. Regulating the development of the … WebApr 15, 2006 · The importance of the IRF family members has been further corroborated by the recent demonstration of their key roles in Toll-like receptor (TLR) signaling in innate and adaptive immune responses. We and others showed that both IRF-5 and IRF-7 interact with MyD88, the adaptor critical for TLR signaling.
Multiple Regulatory Domains of IRF-5 Control Activation, Cellular ...
WebMar 21, 2024 · Also known as IIAE7 Summary This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a … WebSep 6, 2024 · The risk score constructed by IRF family not only acted as an independent factor for predicting survival in CRC patients with different biological processes, signaling pathways and TMB, but also indicated different immunotherapy response with diverse immune and stromal cells infiltration. inbox purpose
Interferon Regulatory Factor 9 Structure and Regulation
WebAug 10, 2024 · All IRF family members involved in antiviral immunity are known to be regulated by phosphorylation, except for IRF9 ( 13 ). The absence of autoinhibitory region from the IRF9 IAD crystal structure reaffirmed previous notions that activation by phosphorylation may not be necessary for IRF9’s association with STAT2 ( 48 ). WebIRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: … WebInterferon regulatory factors (IRFs) constitute a family of transcription factors that commonly possess a novel helix-turn-helix DNA-binding motif. Following the initial … inclination\\u0027s 58