WebAccording to M. Uehara et al., ATM inhibition worsens tubular injury via upregulating p53-dependent pro-apoptotic signaling and does not enhance DNA repair following cisplatin-induced DNA damage. When ATM inhibitors are made available in clinical practice in the future, acute renal injury must be closely monitored ( Uehara et al., 2024 ). WebMay 12, 2024 · Cisplatin is the first-line chemotherapeutic agent for the treatment of oral squamous cell carcinoma (OSCC). However, the intrinsic or acquired resistance against cisplatin remains a major...
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WebAug 1, 1996 · The increased LDR sparing effect in the cisplatin resistant U373MGCP cells indicates increased repair proficiency. The resistant cell line showed a fourfold increase in resistance to cisplatin cytotoxicity at the 10% survival level compared with the parental U373MG cells. Cisplatin enhanced the response of both cell lines to LDRI. WebMar 3, 2008 · A functional MMR system is required for the detection of damaged DNA created by cisplatin and carboplatin ( 23, 24 ). Platinum complexes interfere with normal … how to start up a home daycare
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WebMechanisms explaining cisplatin resistance include the reduction in cisplatin accumulation inside cancer cells because of barriers across the cell membrane, the faster repair of cisplatin adducts, the modulation of apoptotic pathways in various cells, the upregulation in transcription factors, the loss of p53 and other protein functions and a ... WebOct 1, 1995 · Cisplatin, a DNA-damaging agent, is one of the most widely used anticancer drugs. As with all members of this class of chemotherapeutic compounds, the clinical … WebApr 13, 2024 · HIGHLIGHTS. who: Florentine S. B. Subtil et al. from the Department of Radiotherapy and Radiooncology, Philipps-University, Marburg, Germany have published the research: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines, in the … react native placeholder font size